Table of Contents(toc)
Prolonged PT (extrinsic pathway factors):
- Inherited: Factor VII deficiency
- Acquired: mild vitamin K deficiency, Liver disease, warfarin
Prolonged aPTT (intrinsic pathway factors):
- Inherited:
- factors VIII, IX, XI deficiency;
- factor XII,
- Prekallikrein or HMW kininogen deficiency
- Von Willebrand disease
- Acquired:
- Heparin,
- lupus anticoagulant,
- acquired Von Willebrand disease
Prolonged PT and Prolonged aPTT (common pathway factors):
- Inherited:
- Prothrombin (II),
- Fibrinogen (I),
- factor V and factor X deficiencies
- Acquired:
- DIC,
- severe liver disease,
- severe vitamin K deficiency,
- Direct thrombin inhibitor – agratroban,
- dabigatran,
- Direct factor Xa inhibitor – rivaroxaban, apixaban, edoxaban, fondaparinaux
Q. In a patient with normal CBC findings with raise in PTT, what could be the diagnosis?
a) Hemophilia
b) ITP
c) Von-willebrand diease
d) Aplastic anemia
Answer is : A
