What to look for to assess work of breathing in infants and neonates? – Pediatrics Notes

Work of Breathing (WOB) — clinical parameters

Work of breathing is assessed mainly by respiratory effort, chest movement, and signs of respiratory distress.

According to Nelson Textbook of Pediatrics, work of breathing (WOB) refers to the effort required to breathe—i.e., the amount of respiratory muscle activity needed to move air into and out of the lungs.

Clinically, Nelson assesses increased WOB by looking for signs of respiratory distress, particularly:

  • Tachypnea
  • Nasal flaring
  • Retractions/recessions — intercostal, subcostal, suprasternal
  • Grunting
  • Accessory muscle use
  • Head bobbing in infants
  • Paradoxical/see-saw breathing
  • Changes in respiratory pattern or effort

Exam definition

Work of breathing = the effort required to generate ventilation and move air through the respiratory system.

Increased WOB means the child must generate greater-than-normal respiratory effort to maintain adequate ventilation.

High-yield distinction:
WOB ≠ respiratory rate alone. A child can have severe increased WOB even with a relatively normal RR, particularly when respiratory muscle fatigue is developing.

Parameters to assess work of breathing

ParameterWhat to look forSignificance
Respiratory rateTachypnea for ageEarly sign of increased WOB
Nasal flaringAlae nasi widening during inspiration↓ upper-airway resistance
Retractions / recessionSuprasternal, intercostal, subcostal, substernalIncreased negative intrathoracic pressure
GruntingExpiratory gruntMaintains end-expiratory pressure; important neonatal distress sign
Head bobbingEspecially infantsSevere respiratory effort
Tracheal tugDownward movement of trachea on inspirationIncreased inspiratory effort
See-saw/paradoxical breathingChest moves inward while abdomen moves outward, or vice versaSevere distress/fatigue
Accessory muscle useSCM, scalene, abdominal musclesIncreased WOB
Abnormal chest movementAsymmetry, poor expansionAirway/lung pathology
Breath soundsWheeze, stridor, crackles, diminished/absent air entryIdentifies cause/severity
Expiratory phaseProlonged expirationParticularly obstructive disease
GruntingEspecially in neonatesSuggests significant respiratory distress
PostureTripod/sniffing positionCompensatory increase in airway patency
Ability to speak/feedFull sentences vs words; feeding interruption in infantsFunctional measure of WOB
Mental statusIrritability → lethargy → exhaustionLate/severe respiratory compromise
OxygenationSpO₂, cyanosisConsequence rather than direct measure of WOB

Quick severity framework

Mild ↑ WOB

  • Tachypnea
  • Mild nasal flaring
  • Mild intercostal/subcostal recession
  • Child alert and feeding reasonably well

Moderate ↑ WOB

  • Marked retractions
  • Nasal flaring
  • Accessory muscle use
  • Grunting
  • Difficulty feeding/speaking
  • Persistent tachypnea

Severe ↑ WOB / impending failure

  • Severe recession
  • Head bobbing
  • Paradoxical/see-saw breathing
  • Poor air entry or “quiet chest”
  • Exhaustion, altered consciousness
  • Apnea/bradypnea
  • Cyanosis despite oxygen

Important: A falling respiratory rate is not necessarily improvement. In a tiring child, tachypnea may progress to a normal or low RR as respiratory muscles fatigue—often a dangerous sign.

For bedside pediatric assessment, the highest-yield things to document are RR + retractions + nasal flaring + grunting + accessory muscle use + air entry + SpO₂ + mental status/feed/speech ability.

Are you stuck with Diagnosis? Here is prolonged fever + hepatosplenomegaly + persistent leukocytosis diagnoses summarized!

For a child with prolonged fever + hepatosplenomegaly + persistent leukocytosis, I would use the following as a bedside differential/workup table, with particular attention to infections relevant to Nepal and hematologic disease.

1. Infectious causes

DifferentialHistory: ask forExamination cluesKey investigations
TuberculosisContact, chronic cough, weight loss, night sweats, poor appetite; household exposureCervical/generalized nodes, wasting, respiratory signs, hepatosplenomegalyCXR; TST/IGRA; Xpert MTB/RIF/Ultra from appropriate specimen; culture; node FNAC/biopsy if present
Enteric feverProlonged fever, contaminated food/water, travel/outbreak exposure, abdominal symptomsToxicity may be mild; abdominal tenderness, hepatosplenomegaly; relative bradycardia is unreliable in childrenBlood culture before antibiotics; CBC, LFT; stool culture in selected cases
MalariaResidence/travel to endemic Terai areas, mosquito exposure, intermittent/chills patternPallor, jaundice, splenomegaly, hepatomegaly; thrombocytopeniaThick + thin smear + malaria RDT; repeat smear if high suspicion
Visceral leishmaniasisProlonged fever, travel/residence in endemic region, weight lossMassive splenomegaly, hepatomegaly, pallor, wastingrK39/other serology; CBC; confirmatory parasitologic testing when indicated
BrucellosisCattle/goat/sheep exposure, raw/unpasteurized milk, occupational exposure, undulating feverHSM, lymphadenopathy, arthritis; sometimes nonspecificBlood cultures; Brucella serology/PCR where available
EBVSick contacts, sore throat, fatiguePosterior cervical nodes, pharyngitis/tonsillar enlargement, HSMCBC differential, atypical lymphocytes; EBV VCA IgM/IgG ± EBNA; LFT
CMVSick contacts; congenital/perinatal history in younger childHSM, lymphadenopathy; prolonged feverCMV IgM/IgG ± PCR in selected cases; LFT
Scrub typhusRural/forest exposure, mite exposure, recent outdoor activityEschar, rash, lymphadenopathy; hepatosplenomegaly; thrombocytopeniaScrub typhus IgM/ELISA ± PCR
LeptospirosisFloodwater/freshwater, rodents, animal urineConjunctival suffusion, jaundice, renal involvement, myalgiaCBC, renal/LFT; Leptospira PCR/IgM
DengueMosquito exposure, acute febrile illnessRash, bleeding, abdominal tenderness, hepatomegaly; usually thrombocytopeniaCBC trend; NS1/PCR early, IgM later
Disseminated fungal infectionImmunodeficiency, prolonged antibiotics, steroid/immunosuppressive therapyHSM, lymphadenopathy, skin/mucosal lesionsBlood cultures, fungal biomarkers/cultures; imaging/tissue diagnosis
HIVMaternal risk, transfusion, recurrent/opportunistic infections, growth failureGeneralized nodes, HSM, oral candidiasis, wastingHIV Ag/Ab testing; confirmatory algorithm; viral load/CD4 where appropriate
ToxoplasmosisCat/feces exposure, undercooked meat; immunocompromised stateCervical nodes, HSM occasionallyToxoplasma IgM/IgG ± PCR in selected cases
ToxocariasisDogs/cats, soil exposure, picaHepatomegaly, fever, eosinophilia, sometimes ocular diseaseCBC with AEC, Toxocara serology
Hydatid diseaseDog/sheep exposureUsually mass/organ-specific findings rather than feverUSG/CT; Echinococcus serology

2. Hematologic / malignant causes

DifferentialHistoryExaminationInvestigations
ALLFever, fatigue, weight loss, bone/joint pain, bruising, recurrent infectionsPallor, petechiae, lymphadenopathy, HSM, bone tendernessCBC + differential + PBS, retic, LDH/uric acid; bone marrow + flow cytometry if suspected
AMLFever, fatigue, bleeding, infections, bone painPallor, petechiae, HSM, gingival hypertrophy, chloromasCBC/PBS; marrow morphology + flow cytometry/cytogenetics/molecular studies
LymphomaFever, weight loss, night sweats, pruritus; node enlargementFirm/painless nodes, mediastinal signs, HSMCBC, LDH/uric acid; CXR/USG/CT as indicated; excisional lymph-node biopsy
CMLFatigue, weight loss, early satiety, abdominal discomfortMarked splenomegaly, hepatomegaly; pallorCBC differential + PBS; BCR-ABL1 testing, marrow/cytogenetics
JMMLUsually young child; fever, recurrent infections, pallor, rashSplenomegaly, lymphadenopathy, pallor, skin lesionsCBC showing persistent monocytosis, PBS; marrow; molecular testing (e.g. RAS-pathway abnormalities)
Leukemoid reactionInfection/inflammation symptomsUnderlying infectious focus; may have HSMSerial CBC, PBS; neutrophilia/left shift; investigate underlying cause
Hemolytic anemiaJaundice, dark urine, episodic symptoms, drugs/infection/family historyPallor, jaundice, splenomegalyRetic, indirect bilirubin, LDH, haptoglobin, DAT, ± Hb electrophoresis/G6PD

3. Inflammatory / immune causes

DifferentialHistoryExaminationInvestigations
Systemic JIAFever ≥2 weeks, arthritis, rash; fever often quotidianArthritis, evanescent salmon rash, lymphadenopathy, HSMCBC, ESR/CRP, ferritin, LFT; diagnosis is clinical after exclusion
MAS secondary to sJIAPersistent fever, acute deteriorationHSM, rash, bleeding/neurologic changesFerritin, TG, fibrinogen, CBC, AST/ALT, D-dimer
HLHPersistent fever, family history/recurrent episodes, infection triggerSplenomegaly, HSM, lymphadenopathy, neurologic/skin findingsFerritin, TG, fibrinogen, CBC, LFT; sCD25/NK function/genetics in appropriate cases
Kawasaki diseaseFever ≥5 days, irritabilityConjunctival injection, oral changes, rash, extremity changes, cervical nodeCRP/ESR, CBC, LFT, urinalysis; echocardiography
SLEFever, fatigue, rash, photosensitivity, arthralgia, oral ulcersRash, arthritis, alopecia, lymphadenopathy/HSM, hypertensionCBC, ESR/CRP, ANA, dsDNA, C3/C4, urinalysis/proteinuria

4. Important noninfectious causes of HSM

CauseHistory/exam cluesInvestigations
Gaucher diseaseChronic massive HSM, pallor, bone pain/crises, growth issuesβ-glucocerebrosidase enzyme assay ± genetics
Niemann-Pick diseaseHSM + developmental regression/neurologic signsEnzyme/genetic testing
Glycogen storage diseaseHepatomegaly, growth failure, hypoglycemia; fever usually suggests a separate processGlucose, lactate, LFT, metabolic/genetic testing
Chronic liver disease/portal hypertensionJaundice, ascites, bleeding, pruritus, liver disease historyLFT, INR, albumin, viral/autoimmune/metabolic workup, USG Doppler

Particularly important with persistent leukocytosis

Don’t just record the WBC. Break it down:

CBC patternDifferential to prioritize
Neutrophilia + left shiftBacterial infection, occult abscess, leukemoid reaction, inflammatory disease
Very high neutrophils + basophilia + myelocytes/metamyelocytesCML
Persistent monocytosisJMML, TB, brucellosis, chronic infections
Absolute lymphocytosisEBV/CMV, pertussis, viral infection, hematologic disease
EosinophiliaHelminths, Toxocara, drug/allergic disease
BlastsAcute leukemia until proven otherwise
Leukocytosis + anemia + thrombocytopeniaStrongly consider marrow disease/leukemia
Leukocytosis with normal morphology and active childInfection/inflammation or leukemoid reaction more likely, but persistent marked leukocytosis requires further evaluation

A practical initial panel for this child

Given your specific presentation, I would start with:

CBC + differential + platelets + repeat PBS
→ CRP/ESR ± PCT
→ reticulocyte count + MCV/RDW + ferritin
→ LFT/bilirubin/LDH
→ malaria RDT + thick/thin smear
→ blood culture
→ urine R/M + culture
→ USG abdomen

Then based on findings/exposure:

TB testing | EBV/CMV | Brucella | scrub typhus | leptospira | VL/rK39 | stool/parasite testing | Toxocara | HIV | HLH/MAS panel | BCR-ABL1/marrow studies.

For persistent leukocytosis + HSM specifically, I would make sure the report gives the absolute neutrophil, lymphocyte, monocyte, eosinophil and basophil counts—not just total WBC. That single detail can substantially narrow this differential.

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