Usmle mcq questions series 2 – 10 multiple-choice questions (MCQs)

Questions:

1. A 55-year-old man presents with a history of progressive shortness of breath and a chronic productive cough. He has a 40 pack-year smoking history. Physical examination reveals decreased breath sounds and hyperresonance to percussion. What is the most likely diagnosis?

• A) Asthma
• B) Bronchiectasis
• C) Chronic Obstructive Pulmonary Disease (COPD)
• D) Pulmonary Fibrosis
• E) Congestive Heart Failure

A 25-year-old woman presents with fever, malaise, and a maculopapular rash that started on her face and spread to her trunk and extremities. She also has tender postauricular lymphadenopathy. Which of the following is the most likely diagnosis?

• A) Measles
• B) Rubella
• C) Varicella
• D) Roseola
• E) Scarlet Fever

A 60-year-old woman with a history of hypertension presents with sudden-onset severe headache, vomiting, and loss of consciousness. Her blood pressure is 220/130 mmHg. A CT scan of the head shows a hemorrhage. What is the most likely location of the hemorrhage?

• A) Epidural space
• B) Subdural space
• C) Subarachnoid space
• D) Intraparenchymal
• E) Ventricular system

A 32-year-old woman presents with fatigue, weight gain, constipation, and cold intolerance. Physical examination reveals dry skin and a delayed relaxation phase of deep tendon reflexes. Which of the following is the most likely diagnosis?

• A) Hyperthyroidism
• B) Hypothyroidism
• C) Addison’s disease
• D) Cushing’s syndrome
• E) Pheochromocytoma

A 45-year-old man presents with chest pain that occurs at rest and is relieved by nitrates. His ECG shows transient ST-segment elevation during episodes of pain. Which of the following is the most likely diagnosis?

• A) Stable angina
• B) Unstable angina
• C) Myocardial infarction
• D) Prinzmetal’s angina
• E) Pericarditis

A 70-year-old man with a history of chronic kidney disease presents with fatigue, pallor, and decreased exercise tolerance. Laboratory studies reveal a hemoglobin level of 8 g/dL. Which of the following is the most likely cause of his anemia?

• A) Iron deficiency
• B) Vitamin B12 deficiency
• C) Anemia of chronic disease
• D) Hemolytic anemia
• E) Aplastic anemia

A 5-year-old boy presents with a 3-day history of fever, sore throat, and difficulty swallowing. Physical examination reveals an erythematous pharynx with tonsillar exudates and tender cervical lymphadenopathy. What is the most likely causative organism?

• A) Streptococcus pyogenes
• B) Haemophilus influenzae
• C) Epstein-Barr virus
• D) Mycoplasma pneumoniae
• E) Candida albicans

A 40-year-old woman presents with polyuria, polydipsia, and polyphagia. Her fasting blood glucose level is 250 mg/dL. Which of the following is the most likely diagnosis?

• A) Diabetes mellitus type 1
• B) Diabetes mellitus type 2
• C) Diabetes insipidus
• D) Syndrome of inappropriate antidiuretic hormone (SIADH)
• E) Hyperthyroidism

A 30-year-old man presents with a painless, enlarged cervical lymph node. He reports night sweats, fever, and unintentional weight loss over the past 2 months. A lymph node biopsy shows Reed-Sternberg cells. What is the most likely diagnosis?

• A) Non-Hodgkin lymphoma
• B) Hodgkin lymphoma
• C) Metastatic carcinoma
• D) Tuberculosis
• E) Sarcoidosis

A 3-year-old girl is brought to the emergency department with a high fever, drooling, and difficulty breathing. On examination, she is sitting forward with her neck extended and appears anxious. What is the most appropriate next step in management?

• A) Administer oral antibiotics
• B) Obtain a throat culture
• C) Perform a neck X-ray
• D) Secure the airway
• E) Prescribe corticosteroids

Answers:

C) Chronic Obstructive Pulmonary Disease (COPD)
B) Rubella
D) Intraparenchymal
B) Hypothyroidism
D) Prinzmetal’s angina
C) Anemia of chronic disease
A) Streptococcus pyogenes
B) Diabetes mellitus type 2
B) Hodgkin lymphoma
D) Secure the airway